BJOG:高龄孕妇孕期喝酒或上晚班将提高流产几率

据外媒报道,丹麦最新研究报告称,35岁后的妇女怀孕期间如果喝酒、经常上晚班,每天提超过20公斤的重物或是体重超重与太轻,流产的机率将会升高。

据报道,丹麦哥本哈根大学(University of Copenhagen)对超过9万名当地孕妇进行分析研究指出,25%以上第1次流产的案例,事实上都可以避免。

哥本哈根大学资深研究员安德森(Anne-Marie Nybo Andersen)指出,不论是年轻或年长的妇女,连同那些有政策影响力的人都应该了解,35岁后再怀孕大幅提高流产的风险。

她说,这份研究报告传达的重要信息是,流产是可以避免的,不同的生活型态可能造成流产,而不是只是特定的药物所造成。

这篇研究报告刊登在《英国妇产科杂志》(BJOG)上。

安德森表示,这份研究是从人口健康的观点出发,除了夫妇伴侣可以参考,负责怀孕休假政策、工作场所规范者也应该了解。

英国妇产科专家则认为,这篇报告的结论“很有趣”,因为20公斤大约是出门度假时的行李重量,多数人只偶尔才会提这么重的物品。

专家同时建议计划怀孕的妇女要有均衡的饮食,体重不能太轻或太重,自己戒烟并要求枕边人也这样做。

Risk factors for miscarriage from a prevention perspective: a nationwide follow-up study

Objective To identify modifiable risk factors for miscarriage and to estimate the preventable proportion of miscarriages that could be attributed to these. Design Nationwide observational follow-up study. Setting Denmark. Population Ninety-one thousand four hundred and twenty seven pregnancies included in the Danish National Birth Cohort between 1996 and 2002. Methods Information on potentially modifiable risk factors before and during pregnancy was collected by means of computer-assisted telephone interviews and linkage with Danish registers, ensuring almost complete follow-up of pregnancy outcome. Modifiable risk factors for miscarriage were identified by multiple Cox regression analysis, which provided the background for our estimations of population attributable fractions. In all, 88 373 pregnancies had full information on all covariates and were included in this analysis. Main outcome measures Miscarriage before 22 completed weeks of gestation. Results The potentially modifiable pre-pregnant risk factors associated with increased miscarriage risk were: age of 30 years or more at conception, underweight, and obesity. During pregnancy the modifiable risk factors were: alcohol consumption, lifting of >20 kg daily, and night work. We estimated that 25.2% of the miscarriages might be prevented by reduction of all these risk factors to low risk levels. Modification of risk factors acting before and during pregnancy could lead to prevention of 14.7 and 12.5%, respectively, of the miscarriages. Maternal age at conception and alcohol consumption were the most important risk factors. Conclusions Miscarriage risk is increased by multiple potentially modifiable risk factors and a considerable proportion of miscarriages may be preventable.